After reaching a peak weight of around 597 kg (1,320 lb) and having been unable to leave his bed since 2001, Uribe lost approximately 400 lbs. (one-third of his body weight, about 181.8 kg) with the help of doctors and nutritionists, and by following the Zone diet.
Uribe drew worldwide attention when he appeared on the Televisa television network in January 2006, but turned down offers for gastric bypass surgery in Italy.
Uribe has also been featured on The World's Heaviest Man, a television documentary about his bedridden life and attempts to overcome the disease. By October 26, 2008, Uribe had reduced his weight to 360 kg (790 lb). His efforts to overcome the disease continue. In mid 2009, it was falsely reported that Manuel had died. As of February 2012, he weighs 440 lbs.
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